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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. From ethical and scientific validity standpoints, in addition to double blinding, which of the following research designs is best for determining a new medication's relative efficacy in treating acute stroke?

A) Parallel design comparing the new therapy with the best standard therapy
B) Placebo-controlled, randomized, parallel design
C) Crossover design comparing the new therapy with the best standard therapy
D) Placebo-controlled, crossover design

2. A 50-year-old patient presents to the physician complaining of anxiety, insomnia, a depressed mood, and decreased energy level. Paroxetine therapy is initiated. Which symptom will be the last to respond?

A) Anxiety
B) Depressed mood
C) Decreased energy
D) Insomnia

3. A 46-year-old patient begins treatment with allopurinol 300 mg daily following the onset of an acute gout attack due to elevated uric acid.
The patient's other medications are:
* Cyclosporine 800 mg daily
* Prednisone 20 mg daily
* Azathioprine 100 mg daily
* Nifedipine extended release 90 mg daily
Several days later there was an observed decrease in the patient's WBC count. Which drug interaction with allopurinol is most likely to account for this change?

A) Cyclosporine
B) Prednisone
C) Nifedipine
D) Azathioprine

4. An investigator decides to perform a correlation analysis of the relationship between the number of cigarettes smoked per day and age. Results show a positive correlation between the two, with an r value of 0.50 and ap value for the correlation equal to 0.03. What is the most reasonable interpretation of this correlation?

A) Increased age does not cause students to smoke more.
B) There is no relationship between age and amount of smoking.
C) Increased age causes students to Smoke more.
D) There is a statistically significant numerical association between age and amount of smoking.

5. A 70-year-old man has completed a 14-day course of sulfamethoxazole/trimethoprim for Escherichia coli cystourethritis. The patient has a Foley catheter. A urine culture obtained 24 hours after the last antibiotic dose shows Candida albicans > 10x3 cfu/mL, RBC > 100 cells/hpf, and WBC = 10-20 cells/hpf. The patient is asymptomatic. What is the most appropriate management?

A) Posaconazole orally daily for 5-10 days
B) Amphotericin bladder irrigation for 5-10 days
C) No anti-infective needed
D) Fluconazole orally daily for 5-10 days

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