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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Topic 1: Ethical and Participant Safety Considerations19%- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy
- Safety monitoring and reporting
  • 1. Adverse event identification and classification
  • 2. Safety information evaluation and communication
- Clinical care and management of research participants
  • 1. Standard of care vs protocol requirements
  • 2. Continuity of medical care
  • 3. Informed consent development and review
Topic 2: Professionalism and Ethical Practice15%- Continuous improvement
  • 1. Professional development and education
  • 2. Quality assurance and process improvement
- Professional standards
  • 1. Confidentiality and conflict of interest
  • 2. Role responsibilities and boundaries
Topic 3: Clinical Study Operations15%- Site management
  • 1. Study documentation and record keeping
  • 2. Site personnel training and delegation
- Project management
  • 1. Timeline and budget management
  • 2. Vendor and stakeholder management
Topic 4: Study Design and Conduct17%- Study implementation
  • 1. Site selection and activation
  • 2. Study monitoring and oversight
  • 3. Investigational product management
- Study planning
  • 1. Study population and eligibility criteria
  • 2. Protocol development and amendments
  • 3. Sample size and statistical considerations
Topic 5: Data Management and Informatics17%- Data collection
  • 1. Electronic data capture systems
  • 2. Case report form design and completion
- Data reporting
  • 1. Database lock and data transfer
  • 2. Data integrity and security
- Data quality control
  • 1. Data validation and cleaning
  • 2. Query management and resolution
Topic 6: Regulatory and Compliance Requirements17%- International standards
  • 1. Declaration of Helsinki
- Compliance procedures
  • 1. Audits and inspections
  • 2. Regulatory submissions and approvals
- ICH Guidelines
  • 1. E8 General Considerations for Clinical Trials
  • 2. E9 Statistical Principles
  • 3. E6(R2)/E6(R3) Good Clinical Practice
  • 4. E2A Expedited Reporting
  • 5. E11 Pediatric Trials

ACRP Certified Professional Sample Questions:

1. Which of the following elements of the Informed Consent are NOT required?

A) Statement that study involves research
B) A description of potential benefits
C) A description of any reasonably foreseeable risks or discomforts
D) Subject legal rights can be waived


2. After the completion or termination of a clinical trial, who should store the enrollment log?

A) PI
B) Regulatory authority
C) CRO
D) Sponsor


3. In preparation for an upcoming site audit, whose responsibility is it to ensure study-related functions were conducted by qualified personnel?

A) CRC
B) Investigator
C) CRA
D) Sponsor


4. After the site qualification visit report has been finalized, it must be:

A) Stored in the sponsor's budgets and contracts file.
B) Included in the PI's regulatory file.
C) Sent to the IRB/IEC for review and approval.
D) Kept in the CRO/sponsor's trial master file.


5. Which one of the following is a primary objective of a Phase III study of a new IP?

A) To establish dose information
B) To demonstrate or confirm therapeutic benefit
C) To show superiority over another treatment
D) To establish the safety profile


Solutions:

Question # 1
Answer: D
Question # 2
Answer: A
Question # 3
Answer: B
Question # 4
Answer: D
Question # 5
Answer: B

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